来自艾滋病患者的四株双重耐药人巨细胞病毒毒株：UL97和UL54开放阅读框中的单突变分别导致对更昔洛韦和膦甲酸钠的特异性耐药。
Four dually resistant human cytomegalovirus strains from AIDS patients: single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively.
作者信息
Baldanti F, Sarasini A, Silini E, Barbi M, Lazzarin A, Biron K K, Gerna G
机构信息
Viral Diagnostic Service IRCCS Policlinico S. Matteo, Pavia, Italy.
出版信息
Scand J Infect Dis Suppl. 1995;99:103-4.
PMID:8668930
Abstract
Four human cytomegalovirus strains with double resistance to both ganciclovir and foscarnet were recovered from acquired immunodeficiency syndrome (AIDS) patients. The four isolates were genetically unrelated and each of them consisted of a single viral population. In addition, for each isolate, UL97 and UL54 open reading frames sequencing showed a single aminoacid change in a conserved domain of each of the two genes.
摘要
从获得性免疫缺陷综合征（AIDS）患者中分离出四株对更昔洛韦和膦甲酸钠均具有双重耐药性的人巨细胞病毒毒株。这四株分离株在基因上无关联，且每株均由单一病毒群体组成。此外，对每株分离株的UL97和UL54开放阅读框进行测序，结果显示这两个基因的保守结构域中均有一个氨基酸发生了改变。
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