Hodinka R L
Division of Immunologic and Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, USA.
Infect Dis Clin North Am. 1997 Dec;11(4):945-67. doi: 10.1016/s0891-5520(05)70399-8.
The development of safe and effective antiviral therapies for the management of a variety of viral infections has expanded tremendously in recent years. Treatment is now possible for serious and potentially life-threatening infections with herpesviruses, respiratory viruses such as influenza A and respiratory syncytial virus, and the human immunodeficiency virus. The increased availability and use of antiviral drugs, however, has led to the emergence of drug-resistant viruses, especially in immunocompromised hosts. With this review, the major antiviral agents are presented with a description of the mechanisms of action, the evolution of drug resistance, and the need for in vitro antiviral susceptibility testing.
近年来,用于治疗各种病毒感染的安全有效的抗病毒疗法有了极大的发展。现在可以治疗由疱疹病毒、甲型流感和呼吸道合胞病毒等呼吸道病毒以及人类免疫缺陷病毒引起的严重且可能危及生命的感染。然而,抗病毒药物的可获得性增加和使用导致了耐药病毒的出现,尤其是在免疫功能低下的宿主中。通过这篇综述,介绍了主要的抗病毒药物,描述了其作用机制、耐药性的演变以及体外抗病毒药敏试验的必要性。