Toropainen E M, Lipponen P K, Syrjanen K J
Department of Pathology, University of Kuopio, Finland.
Anticancer Res. 1995 Nov-Dec;15(6B):2669-74.
The expression of insulin-like growth factor II (IGF-II) was analysed immunohistochemically in a series of 211 breast cancers with special reference to standard prognostic factors and patient survival. IGF-II was expressed both in the cancer cells and in stromal cells, in 84% and 50% of cases, respectively. IGF-II expression in cancer cells was related to a non-metastatic disease at diagnosis (p = 0.03), low tumour grade (p = 0.02), DNA diploidy (p = 0.02) and S-phase fraction under 7% (p = 0.001). IGF-II negativity was positively correlated to morphometric SD of nuclear area (p = 0.0003), nuclear perimetry (p = 0.002), SD of nuclear perimetry (p = 0.02), minimum nuclear diameter (p = 0.005) and maximum nuclear diameter (p = 0.003). The expression of IGF-II in stromal cells was related to low histological grade (p = 0.02), mitotic index under 10/mm2 (p = 0.01), mild nuclear pleomorphism (p = 0.03), DNA diploidy (p = 0.08), SD of nuclear area (p = 0.006), mean nuclear perimeter (p = 0.05), minimum nuclear diameter (p = 0.005) and maximum nuclear diameter (p = 0.007) in that the nuclear factor values were higher in tumours without stromal IGF-II expression. In univariate and multivariate survival analysis, immunohisto-chemically detected expression of IGF-II had no independent prognostic value over standard prognostic factors. Despite the fact that expression of IGF-II was inversely related to several histopathological features of malignancy, the clinical behaviour of breast cancer seemed to be independent of IGF-II expression.
采用免疫组织化学方法分析了211例乳腺癌中胰岛素样生长因子II（IGF-II）的表达情况，并特别参考了标准预后因素和患者生存率。IGF-II在癌细胞和基质细胞中均有表达，分别见于84%和50%的病例。癌细胞中IGF-II的表达与诊断时的非转移性疾病（p = 0.03）、低肿瘤分级（p = 0.02）、DNA二倍体（p = 0.02）以及S期分数低于7%（p = 0.001）相关。IGF-II阴性与核面积的形态计量标准差（p = 0.0003）、核周长（p = 0.002）、核周长标准差（p = 0.02）、最小核直径（p = 0.005）和最大核直径（p = 0.003）呈正相关。基质细胞中IGF-II的表达与低组织学分级（p = 0.02）、有丝分裂指数低于10/mm²（p = 0.01）、轻度核多形性（p = 0.03）、DNA二倍体（p = 0.08）、核面积标准差（p = 0.006）、平均核周长（p = 0.05）、最小核直径（p = 0.005）和最大核直径（p = 0.007）相关，因为在无基质IGF-II表达的肿瘤中核因子值更高。在单变量和多变量生存分析中，免疫组织化学检测到的IGF-II表达相对于标准预后因素没有独立的预后价值。尽管IGF-II的表达与恶性肿瘤的几个组织病理学特征呈负相关，但乳腺癌的临床行为似乎与IGF-II表达无关。
