Senkevich T G, Bugert J J, Sisler J R, Koonin E V, Darai G, Moss B
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0455, USA.
Science. 1996 Aug 9;273(5276):813-6. doi: 10.1126/science.273.5276.813.
Molluscum contagiosum virus (MCV) commonly causes asymptomatic cutaneous neoplasms in children and sexually active adults as well as persistent opportunistic acquired immunodeficiency syndrome (AIDS)-associated disease. Sequencing the 190-kilobase pair genome of MCV has now revealed that the virus potentially encodes 163 proteins, of which 103 have homologs in the smallpox virus. MCV lacks counterparts to 83 genes of the smallpox virus, including those important in suppression of host responses to infection, nucleotide biosynthesis, and cell proliferation. MCV possesses 59 genes that are predicted to encode previously uncharacterized proteins, including major histocompatibility complex class I, chemokine, and glutathione peroxidase homologs, which suggests that there are MCV-specific strategies for coexistence with the human host.
传染性软疣病毒（MCV）通常会在儿童、性活跃的成年人以及持续性机会性获得性免疫缺陷综合征（AIDS）患者中引发无症状性皮肤肿瘤。对MCV的190千碱基对基因组进行测序后发现，该病毒可能编码163种蛋白质，其中103种在天花病毒中有同源物。MCV缺少天花病毒83个基因的对应物，包括那些在抑制宿主对感染的反应、核苷酸生物合成和细胞增殖方面很重要的基因。MCV拥有59个预计编码以前未被表征的蛋白质的基因，包括主要组织相容性复合体I类、趋化因子和谷胱甘肽过氧化物酶同源物，这表明存在MCV与人类宿主共存的特定策略。
