Kabasakal Y, Garrett S L, Calin A
Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath.
Br J Rheumatol. 1996 Jul;35(7):660-3. doi: 10.1093/rheumatology/35.7.660.
Spondylodiscitis is well recognized in ankylosing spondylitis (AS), but little is known about its epidemiology. We therefore reviewed 147 consecutive patients with AS using lumbar and thoracic spine radiographs. For each patient with spondylodiscitis, two age- and sex-matched controls were selected. Twelve individuals (8%) had spondylodiscitis, affecting a total of 32 disc spaces: 10 thoracic, 22 lumbar. The mean age at onset was 21 +/- 4.1 yr, significantly younger than that of the controls (28.5 +/- 10.1 yr, P = 0.004). Half of the 12 patients had multiple lesions (between two and six levels). The most common site was the lower thoracic spine with additional lumbar spine involvement. Only two of the 12 patients (17%) had symptoms localized to the lesions. Neither trauma nor infection were considered to be causes of the spondylodiscitis.
(1) spondylodiscitis occurs in approximately 8% of patients with AS; (2) these patients have early onset of disease; (3) multiple-level lesions in the spine are not uncommon among those with spondylodiscitis; (4) lesions are usually asymptomatic.
脊柱椎间盘炎在强直性脊柱炎（AS）中已得到充分认识，但对其流行病学了解甚少。因此，我们使用腰椎和胸椎X线片对147例连续性AS患者进行了回顾性研究。对于每例患有脊柱椎间盘炎的患者，选择两名年龄和性别匹配的对照。12例（8%）患者患有脊柱椎间盘炎，共累及32个椎间盘间隙：10个胸椎间隙，22个腰椎间隙。发病的平均年龄为21±4.1岁，显著低于对照组（28.5±10.1岁，P = 0.004）。12例患者中有一半有多个病变（2至6个节段）。最常见的部位是下胸椎，伴有腰椎受累。12例患者中只有2例（17%）有局限于病变部位的症状。外伤和感染均不被认为是脊柱椎间盘炎的病因。
（1）脊柱椎间盘炎发生于约8%的AS患者中；（2）这些患者发病早；（3）脊柱多节段病变在脊柱椎间盘炎患者中并不少见；（4）病变通常无症状。
