Halila H
Tumour Biol. 1985;6(3):207-12.
Ovarian cancer marker CA 125-like immunoreactivity was detected in human seminal plasma. The levels were 17-720 U/ml in specimens from normospermic men (n = 35), 22-1150 U/ml in samples from 46 men with either oligo-, astheno-, terato- or necrospermia, and 36-1096 U/ml in 7 vasectomized men. No significant differences were found in the CA 125 levels between the groups studied. Low CA 125 levels (less than 35 U/ml) were detected in male sera. Serial dilutions of seminal plasma and ovarian cancer serum gave parallel dose-response curves. No correlation was observed between the age of men, sperm count, volume of seminal plasma or percent of motile spermatozooa and CA 125 levels in seminal plasma. CA 125 in seminal plasma does not seem to be of testicular origin, as the levels in vasectomized and non-vasectomized men were similar. In gel filtration, CA 125 immunoreactivity in seminal plasma and ovarian cancer serum eluted in the same volume corresponding to a molecular weight of about 130 kD.
在人类精浆中检测到了卵巢癌标志物CA 125样免疫反应性。正常精子男性（n = 35）标本中的水平为17 - 720 U/ml，46例少精、弱精、畸精或死精男性样本中的水平为22 - 1150 U/ml，7例输精管结扎男性中的水平为36 - 1096 U/ml。在所研究的组之间，CA 125水平未发现显著差异。在男性血清中检测到低CA 125水平（低于35 U/ml）。精浆和卵巢癌血清的系列稀释给出了平行的剂量反应曲线。未观察到男性年龄、精子计数、精浆体积或活动精子百分比与精浆中CA 125水平之间的相关性。精浆中的CA 125似乎并非睾丸来源，因为输精管结扎男性和未输精管结扎男性中的水平相似。在凝胶过滤中，精浆和卵巢癌血清中的CA 125免疫反应性在相同体积处洗脱，对应分子量约为130 kD。
