胎儿滋养层细胞分泌炎性细胞因子和前列腺素可诱导子宫收缩和分娩发动。
[Secretion of inflammatory cytokines and prostaglandins by fetal trophoblast cells induces uterine contraction and labor onset].
作者信息
Steinbron A, Günes H, Lechner B, Halberstadt E
机构信息
Zentrum für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Frankfurt.
出版信息
Gynakol Geburtshilfliche Rundsch. 1995;35 Suppl 1:83-7. doi: 10.1159/000272570.
OBJECTIVE
Induce infection-associated cytokines intrauterine secretion of prostaglandins and term labor?
METHODS
Concentrations of Il-6, Il-1 beta, TNF-alpha, PGF2 and PGF2 alpha were determined in cervical secretions and amniotic fluid during spontaneous term labor. The supernatant of amnion-, chorion-, decidua- and trophoblast cells, cultured after elective cesarean section or spontaneous delivery, was analysed for cytokine- and prostaglandin activity.
RESULTS
Term labor always is associated with intrauterine cytokine- and prostaglandin release. Increased production of cytokines and prostaglandins in case of normal term labor only was found by fetal trophoblast cells.
CONCLUSIONS
Signal for parturition is of trophoblast and therefore of fetal origin.
目的
诱导与感染相关的细胞因子在子宫内分泌前列腺素并引发足月分娩？
方法
在自然足月分娩期间，测定宫颈分泌物和羊水中白细胞介素-6（Il-6）、白细胞介素-1β（Il-1β）、肿瘤坏死因子-α（TNF-α）、前列腺素F2（PGF2）和前列腺素F2α（PGF2α）的浓度。对择期剖宫产或自然分娩后培养的羊膜、绒毛膜、蜕膜和滋养层细胞的上清液进行细胞因子和前列腺素活性分析。
结果
足月分娩总是与子宫内细胞因子和前列腺素的释放有关。仅在正常足月分娩时，发现胎儿滋养层细胞产生的细胞因子和前列腺素增加。
结论
分娩信号来自滋养层，因此源于胎儿。
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