Klabunde C, Kaluzny A, Ford L
Health Policy and Administration, School of Public Health, University of North Carolina at Chapel Hill 27599, USA.
Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov;4(7):783-9.
Cancer prevention and control involves a diverse spectrum of activities that range from preventing the disease to providing rehabilitation to its survivors. The range of activities included within the definition of cancer prevention and control makes it difficult to determine factors that would predict accrual to specific cancer prevention and control trials. The participation of 36 CCOP organization in the National Cancer Institute-sponsored Breast Cancer PRevention TRial (BCPT) presented the opportunity to assess the ability of Community Clinical Oncology Program (CCOPs) to enroll subjects in one of the nation's first large-scale cancer prevention trials and to compare characteristics of CCOP accrual to the BCPT with factors associated with accrual by CCOPs to cancer treatment and other cancer prevention and control clinical trials. Although representing only 13% of participating health care organizations, CCOPs presently contribute nearly 30% of total BCPT accrual. Comparison of regression models representing accrual to treatment, cancer control, and chemoprevention (i.e., BCPT) protocols shows similar predictors between treatment and chemoprevention models. Cancer control models, however, did not share similar predictors. Thus, accrual to chemoprevention trials is associated, to a greater extent, with the characteristics that facilitate accrual to treatment trials rather than to cancer control trials. Results have implications for the planning and ongoing management of cancer treatment, control, and chemoprevention clinical trials.
癌症预防与控制涉及一系列广泛的活动，从预防疾病到为幸存者提供康复服务。癌症预防与控制定义中所包含的活动范围使得难以确定能够预测参与特定癌症预防与控制试验的因素。36个社区临床肿瘤项目（CCOP）组织参与了美国国立癌症研究所资助的乳腺癌预防试验（BCPT），这提供了一个机会来评估社区临床肿瘤项目（CCOP）在该国首个大规模癌症预防试验之一中招募受试者的能力，并将CCOP参与BCPT的特征与CCOP参与癌症治疗及其他癌症预防与控制临床试验的招募相关因素进行比较。尽管CCOP仅占参与医疗保健组织的13%，但目前它们贡献了BCPT总招募人数的近30%。对代表参与治疗、癌症控制和化学预防（即BCPT）方案的回归模型进行比较，结果显示治疗模型和化学预防模型之间存在相似的预测因素。然而，癌症控制模型没有共享相似的预测因素。因此，参与化学预防试验在更大程度上与促进参与治疗试验而非癌症控制试验的特征相关。研究结果对癌症治疗、控制和化学预防临床试验的规划及持续管理具有启示意义。
