Kollerstrom N, Lord P W, Whimster W F
Thorax. 1977 Apr;32(2):155-9. doi: 10.1136/thx.32.2.155.
The ratio of the amount of sulphated to sialic acid mucin (Su/Si) in the mucous glands of the human tracheobronchial tree has been investigated in seven smokers and seven non-smokers. The two mucins were studied in histological sections stained by the high iron diamine/Alcian blue pH 2-5 sequence and assessed by a point-counting method. Su/Si was greater in the smokers than in the non-smokers, who were almost completely distinguished by this ratio. A decrease in the ratio with each generation of branching from the trachea down the inferior lingular bronchial segmental pathway was seen in both the smoking and non-smoking groups. Analysis of the logarithm of Su/Si showed the smoking group means to be 2-3 times that of the non-smokers at each generation, and over both groups the average decrease down successive generations was given by a factor of 0-9.
对7名吸烟者和7名不吸烟者的人气管支气管树黏液腺中硫酸化黏蛋白与唾液酸黏蛋白的量之比（Su/Si）进行了研究。通过高铁二胺/阿尔辛蓝pH 2 - 5序列染色的组织切片对这两种黏蛋白进行研究，并采用点计数法进行评估。吸烟者的Su/Si高于不吸烟者，几乎完全可以通过该比例区分这两组人。在吸烟组和非吸烟组中，从气管沿下舌叶支气管节段路径向下每一代分支，该比例均降低。对Su/Si的对数分析表明，在每一代中，吸烟组的平均值是非吸烟者的2 - 3倍，并且在两组中，连续几代的平均降低系数为0.9。
