Turjman F, Xavier J L, Froment J C, Tran-Minh V A, David L, Lapras C
Department of Radiology, Hôpital Neurologique, Lyon, France.
Childs Nerv Syst. 1996 Feb;12(2):63-8. doi: 10.1007/BF00819496.
The absence of changes over time in the diagnostic features of suspected hypothalamic hamartomas is of paramount importance. Since magnetic resonance (MR) imaging is very sensitive to modifications in the brain parenchyma, a late MR follow-up study was performed in five children. In all cases, the diagnosis of hypothalamic hamartoma has been suspected on the basis of the association of central precocious puberty and the presence of a mass in the inferior aspect of the hypothalamus, demonstrated on previous MR studies. Late MR evaluation (after a mean of 39 months) demonstrated stability of the lesions in shape, size, and signal intensity. In three cases the lesions demonstrated a rim of isointense signal with a hyperintense center on T2-weighted sequences. In two cases a Chiari I malformation was found in association with the hypothalamic malformation. In one case a pineal cyst was demonstrated. These unusual findings are discussed. Late MR follow-up showed the absence of changes in the lesions over time, allowing the diagnosis to be confirmed.
疑似下丘脑错构瘤的诊断特征未随时间发生变化，这一点至关重要。由于磁共振（MR）成像对脑实质的改变非常敏感，因此对5名儿童进行了晚期MR随访研究。在所有病例中，根据中枢性性早熟以及下丘脑下方存在肿块的关联，先前的MR研究已怀疑为下丘脑错构瘤。晚期MR评估（平均39个月后）显示病变在形状、大小和信号强度方面保持稳定。在3例病例中，病变在T2加权序列上显示等信号边缘和高信号中心。在2例病例中，发现小脑扁桃体下疝畸形与下丘脑畸形相关。在1例病例中发现了松果体囊肿。对这些不寻常的发现进行了讨论。晚期MR随访显示病变未随时间发生变化，从而确诊。
