Volm M, Koomagi R, Kaufmann M, Mattern J, Stammler G
German Cancer Research Center, University of Heidelberg, Germany.
Clin Exp Metastasis. 1996 May;14(3):209-14. doi: 10.1007/BF00053893.
Relationships between the incidence of metastatic spread and microvessel density, expression of proto-oncogene products, or expression of resistance-related proteins were investigated in human ovarian carcinomas by immunohistochemistry. Ovarian carcinomas with a high microvessel density showed a significantly increased formation of metastases (P = 0.005). Tumors with positive immunoreactivity of c-jun and c-myc products had a higher metastatic spread; however, these results were not statistically significant. A marginally significant correlation existed between the expression of erbB1 (EGFR) and metastatic spread (P = 0.05). No significant relationship was found between the expression of the resistance-related proteins P-glycoprotein or glutathione S-transferase-pi and the incidence of metastases. Furthermore, no correlation was detected between expression of the heat shock protein 70 and the occurrence of metastases.
通过免疫组织化学方法，在人卵巢癌中研究了转移扩散发生率与微血管密度、原癌基因产物表达或耐药相关蛋白表达之间的关系。微血管密度高的卵巢癌转移形成显著增加（P = 0.005）。c-jun和c-myc产物免疫反应阳性的肿瘤转移扩散更高；然而，这些结果无统计学意义。erbB1（表皮生长因子受体）表达与转移扩散之间存在边缘显著相关性（P = 0.05）。未发现耐药相关蛋白P-糖蛋白或谷胱甘肽S-转移酶-pi的表达与转移发生率之间存在显著关系。此外，未检测到热休克蛋白70的表达与转移发生之间存在相关性。
