Généreau T, Bellin M F, Wechsler B, Le T H, Bellanger J, Grellet J, Godeau P
Department of Internal Medicine, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Dig Dis Sci. 1996 Apr;41(4):684-8. doi: 10.1007/BF02213123.
Sclerosing mesenteritis is an uncommon condition of unknown etiology. It is likely to be the fibrous evolution of mesenteric panniculitis. It often has an indolent course but may be complicated by progressive bowel obstruction. The treatment of the symptomatic forms is not well established. The observations of two women (20 and 65 years old) with a relentless downhill course of biopsy-proved sclerosing mesenteritis are described. A treatment regimen with corticosteroid therapy (initially 1 mg/kg/day) and colchicine (1 mg/day) led, in both cases, to a rapid improvement. Abdominal computer tomography showed reduction in the tumor size. The combination of corticosteroids and colchicine is helpful in the management of symptomatic sclerosing mesenteritis. Follow-up with abdominal computed tomography is useful in evaluating the therapeutic impact.
硬化性肠系膜膜炎是一种病因不明的罕见病症。它可能是肠系膜脂膜炎的纤维化演变。其病程通常较为隐匿，但可能并发进行性肠梗阻。有症状型的治疗方法尚未明确。本文描述了两名女性患者（分别为20岁和65岁）活检证实为硬化性肠系膜膜炎且病情持续恶化的情况。在这两个病例中，采用皮质类固醇疗法（初始剂量为1毫克/千克/天）和秋水仙碱（1毫克/天）的治疗方案均使病情迅速改善。腹部计算机断层扫描显示肿瘤大小缩小。皮质类固醇和秋水仙碱联合使用有助于有症状的硬化性肠系膜膜炎的治疗。腹部计算机断层扫描随访有助于评估治疗效果。
