Jamieson D J, Stephen D W, Terrière E C
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, UK.
FEMS Microbiol Lett. 1996 Apr 15;138(1):83-8. doi: 10.1111/j.1574-6968.1996.tb08139.x.
Treatment of Candida albicans with low concentrations of either hydrogen peroxide or menadione (a superoxide generating agent) induces an adaptive response which protects cells from the lethal effects of a subsequent challenge with higher concentrations of these oxidants. Pre-treatment with either menadione or hydrogen peroxide is protective against cell killing by either oxidant. This suggests that the pathogenic yeast C. albicans (unlike the budding yeast Saccharomyces cerevisiae which has separate responses) possesses an adaptive response that responds to both these oxidants. In addition, we found that C. albicans showed a greater level of resistance to oxidants, both H2O2 and redox-cycling agents, compared to that observed with S. cerevisiae. In an attempt to characterise the oxidative stress response in more detail we have analysed the effect of oxidants on the activities of a number of enzymes with known antioxidant activity.
用低浓度的过氧化氢或甲萘醌（一种超氧化物生成剂）处理白色念珠菌会诱导一种适应性反应，这种反应可保护细胞免受随后更高浓度这些氧化剂攻击的致死效应。用甲萘醌或过氧化氢预处理可防止细胞被任何一种氧化剂杀死。这表明致病酵母白色念珠菌（与具有不同反应的出芽酵母酿酒酵母不同）拥有一种对这两种氧化剂都有反应的适应性反应。此外，我们发现与酿酒酵母相比，白色念珠菌对氧化剂（H2O2和氧化还原循环剂）表现出更高水平的抗性。为了更详细地描述氧化应激反应，我们分析了氧化剂对多种具有已知抗氧化活性的酶活性的影响。
