Pryjma J, Baran J, Zembala M
Department of Clinical Immunology and Microbiology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland.
Immunol Invest. 1996 Jan-Mar;25(1-2):1-11. doi: 10.3109/08820139609059286.
Monocytes are eliminated from cell culture by antigen or mitogen activated cytotoxic CD4+ T-lymphocytes. In this report we asked the question whether CD4+CD45RA+ and CD4+CD45RO+ subpopulations differ in the ability to kill monocytes in pokeweed mitogen (PWM)-activated cultures. Data are presented that although CD4+CD45RA+ vigorously proliferate in the presence of PWM, they do not kill monocytes or secrete IFN gamma.