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1
New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.某些新型减毒活霍乱疫苗以及埃尔托型霍乱弧菌和Q139霍乱弧菌所致腹泻中存在炎症成分的新证据。
Infect Immun. 1996 Jun;64(6):2362-4. doi: 10.1128/iai.64.6.2362-2364.1996.
2
Safety and immunogenicity of live oral cholera vaccine candidate CVD 110, a delta ctxA delta zot delta ace derivative of El Tor Ogawa Vibrio cholerae.口服霍乱活疫苗候选株CVD 110（埃尔托小川型霍乱弧菌的ctxA缺失、zot缺失、ace缺失衍生物）的安全性和免疫原性
J Infect Dis. 1993 Dec;168(6):1536-40. doi: 10.1093/infdis/168.6.1536.
3
Genetic manipulation of Vibrio cholerae for vaccine development: construction of live attenuated El Tor candidate vaccine strains.用于疫苗开发的霍乱弧菌基因操作：减毒活El Tor候选疫苗株的构建
Arch Med Res. 1996 Autumn;27(3):275-83.
4
Texas Star-SR: attenuated "Vibrio cholerae" oral vaccine candidate.德克萨斯之星-SR：减毒口服霍乱弧菌候选疫苗
Dev Biol Stand. 1983;53:59-65.
5
Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challenge with Vibrio cholerae O1 El tor inaba three months after vaccination.单剂量口服霍乱活疫苗CVD 103-HgR接种三个月后，用霍乱弧菌O1 El tor稻叶型毒株攻击，预防霍乱效果的随机、双盲、安慰剂对照、多中心试验。
Infect Immun. 1999 Dec;67(12):6341-5. doi: 10.1128/IAI.67.12.6341-6345.1999.
6
Peru-15, an improved live attenuated oral vaccine candidate for Vibrio cholerae O1.秘鲁-15，一种用于霍乱弧菌O1型的改良口服减毒活疫苗候选株。
J Infect Dis. 1995 Oct;172(4):1126-9. doi: 10.1093/infdis/172.4.1126.
7
Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins.霍乱弧菌毒素对促炎免疫反应的激活与抑制
Microbes Infect. 2003 Nov;5(13):1241-7. doi: 10.1016/j.micinf.2003.08.007.
8
CVD110, an attenuated Vibrio cholerae O1 El Tor live oral vaccine strain.CVD110，一种减毒的霍乱弧菌O1埃尔托型口服活疫苗菌株。
Infect Immun. 1993 Oct;61(10):4462-8. doi: 10.1128/iai.61.10.4462-4468.1993.
9
Process development for a Cuban cholera vaccine based on the attenuated strain Vibrio cholerae 638.
Vaccine. 2006 May 1;24(18):3746-9. doi: 10.1016/j.vaccine.2005.07.015. Epub 2005 Aug 8.
10
New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh.从孟加拉国急性腹泻住院患者中分离出具有古典生物型特征的霍乱弧菌O1生物型埃尔托新变种。
J Clin Microbiol. 2002 Sep;40(9):3296-9. doi: 10.1128/JCM.40.9.3296-3299.2002.

引用本文的文献

1
Post-infection irritable bowel syndrome in the tropical and subtropical regions: Vibrio cholerae is a new cause of this well-known condition.热带和亚热带地区感染后肠易激综合征：霍乱弧菌是这种常见病症的新病因。
Indian J Gastroenterol. 2019 Apr;38(2):87-94. doi: 10.1007/s12664-019-00959-2.
2
Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways.霍乱对人类黏膜免疫反应的分析揭示了固有免疫信号通路的持续激活。
Infect Immun. 2018 Jan 22;86(2). doi: 10.1128/IAI.00594-17. Print 2018 Feb.
3
Quantifying Vibrio cholerae Enterotoxicity in a Zebrafish Infection Model.在斑马鱼感染模型中对霍乱弧菌肠毒性进行定量分析。
Appl Environ Microbiol. 2017 Aug 1;83(16). doi: 10.1128/AEM.00783-17. Print 2017 Aug 15.
4
Vibrio cholerae hemagglutinin(HA)/protease: An extracellular metalloprotease with multiple pathogenic activities.霍乱弧菌血凝素（HA）/蛋白酶：一种具有多种致病活性的细胞外金属蛋白酶。
Toxicon. 2016 Jun 1;115:55-62. doi: 10.1016/j.toxicon.2016.03.003. Epub 2016 Mar 4.
5
Vibrio cholerae-induced inflammation in the neonatal mouse cholera model.霍乱弧菌引起的新生鼠霍乱模型中的炎症反应。
Infect Immun. 2014 Jun;82(6):2434-47. doi: 10.1128/IAI.00054-14. Epub 2014 Mar 31.
6
Promotion of colonization and virulence by cholera toxin is dependent on neutrophils.霍乱毒素促进定植和毒力依赖于中性粒细胞。
Infect Immun. 2013 Sep;81(9):3338-45. doi: 10.1128/IAI.00422-13. Epub 2013 Jun 24.
7
Vibrio cholerae: lessons for mucosal vaccine design.霍乱弧菌：黏膜疫苗设计的启示。
Expert Rev Vaccines. 2011 Jan;10(1):79-94. doi: 10.1586/erv.10.150.
8
TagA is a secreted protease of Vibrio cholerae that specifically cleaves mucin glycoproteins.TagA 是霍乱弧菌分泌的一种丝氨酸蛋白酶，可特异性切割粘蛋白糖蛋白。
Microbiology (Reading). 2011 Feb;157(Pt 2):516-525. doi: 10.1099/mic.0.044529-0. Epub 2010 Oct 21.
9
Back to the future: studying cholera pathogenesis using infant rabbits.回到未来：使用幼兔研究霍乱发病机制。
mBio. 2010 May 18;1(1):e00047-10. doi: 10.1128/mBio.00047-10.
10
Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins.减毒活霍乱疫苗的反应原性依赖于鞭毛蛋白。
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4359-64. doi: 10.1073/pnas.0915164107. Epub 2010 Feb 16.

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5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.5'-单磷酸腺苷是一种源自中性粒细胞的旁分泌因子，可引起T84肠上皮细胞单层的氯离子分泌。
J Clin Invest. 1993 May;91(5):2320-5. doi: 10.1172/JCI116462.
2
Safety and immunogenicity of live oral cholera vaccine candidate CVD 110, a delta ctxA delta zot delta ace derivative of El Tor Ogawa Vibrio cholerae.口服霍乱活疫苗候选株CVD 110（埃尔托小川型霍乱弧菌的ctxA缺失、zot缺失、ace缺失衍生物）的安全性和免疫原性
J Infect Dis. 1993 Dec;168(6):1536-40. doi: 10.1093/infdis/168.6.1536.
3
Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils.鼠伤寒沙门氏菌与人肠道上皮单层细胞的附着：向黏膜下中性粒细胞的跨细胞信号传导
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Comparison of fecal lactoferrin latex agglutination assay and methylene blue microscopy for detection of fecal leukocytes in Clostridium difficile-associated disease.粪便乳铁蛋白乳胶凝集试验与亚甲蓝显微镜检查在艰难梭菌相关性疾病中检测粪便白细胞的比较
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A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.作为对细菌入侵的反应，人类结肠上皮细胞会表达一系列独特的促炎细胞因子。
J Clin Invest. 1995 Jan;95(1):55-65. doi: 10.1172/JCI117676.
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Extension of the volunteer challenge model to study South American cholera in a population of volunteers predominantly with blood group antigen O.
Trans R Soc Trop Med Hyg. 1995 Jan-Feb;89(1):75-7. doi: 10.1016/0035-9203(95)90667-3.
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Clinical and immunologic characteristics of Vibrio cholerae O139 Bengal infection in North American volunteers.北美志愿者中霍乱弧菌O139孟加拉感染的临床和免疫学特征
J Infect Dis. 1995 Apr;171(4):903-8. doi: 10.1093/infdis/171.4.903.
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Safety, immunogenicity, and efficacy of recombinant live oral cholera vaccines, CVD 103 and CVD 103-HgR.重组活口服霍乱疫苗CVD 103和CVD 103-HgR的安全性、免疫原性及有效性
Lancet. 1988 Aug 27;2(8609):467-70. doi: 10.1016/s0140-6736(88)90120-1.
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Adhesion-dependent activation of mucosal interleukin-6 production.黏膜白细胞介素-6产生的黏附依赖性激活。
Infect Immun. 1991 Dec;59(12):4357-62. doi: 10.1128/iai.59.12.4357-4362.1991.
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Biological role of lactoferrin.乳铁蛋白的生物学作用。
Arch Dis Child. 1992 May;67(5):657-61. doi: 10.1136/adc.67.5.657.

某些新型减毒活霍乱疫苗以及埃尔托型霍乱弧菌和Q139霍乱弧菌所致腹泻中存在炎症成分的新证据。

New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.

作者信息

Silva T M, Schleupner M A, Tacket C O, Steiner T S, Kaper J B, Edelman R, Guerrant R

机构信息

Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville, USA.

出版信息

Infect Immun. 1996 Jun;64(6):2362-4. doi: 10.1128/iai.64.6.2362-2364.1996.

DOI:10.1128/iai.64.6.2362-2364.1996
PMID:8675353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174082/
Abstract

Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.

摘要

我们使用乳铁蛋白乳胶凝集试验，比较了一种霍乱疫苗候选株CVD 110、反应较弱的疫苗株、野生型埃尔托霍乱弧菌和0139霍乱弧菌菌株的炎症反应。CVD 110中所有已知的毒素基因均已缺失或突变，但仍会引起明显腹泻。数据表明，减毒和野生型埃尔托霍乱弧菌引起的腹泻，以及程度较轻的0139霍乱弧菌引起的腹泻，都涉及炎症反应。需要进一步研究以进一步阐明其中涉及的过程机制。