某些新型减毒活霍乱疫苗以及埃尔托型霍乱弧菌和Q139霍乱弧菌所致腹泻中存在炎症成分的新证据。
New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.
作者信息
Silva T M, Schleupner M A, Tacket C O, Steiner T S, Kaper J B, Edelman R, Guerrant R
机构信息
Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville, USA.
出版信息
Infect Immun. 1996 Jun;64(6):2362-4. doi: 10.1128/iai.64.6.2362-2364.1996.
Abstract
Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.
摘要
我们使用乳铁蛋白乳胶凝集试验，比较了一种霍乱疫苗候选株CVD 110、反应较弱的疫苗株、野生型埃尔托霍乱弧菌和0139霍乱弧菌菌株的炎症反应。CVD 110中所有已知的毒素基因均已缺失或突变，但仍会引起明显腹泻。数据表明，减毒和野生型埃尔托霍乱弧菌引起的腹泻，以及程度较轻的0139霍乱弧菌引起的腹泻，都涉及炎症反应。需要进一步研究以进一步阐明其中涉及的过程机制。
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