囊性纤维化的基因治疗：挑战与未来方向 - Suppr

Suppr

超能文献

Gene therapy for cystic fibrosis: challenges and future directions.

作者信息

Wilson J M

机构信息

Institute for Human Gene Therapy, Wistar Institute, Philadelphia, Pennsylvania, 19104, USA.

出版信息

J Clin Invest. 1995 Dec;96(6):2547-54. doi: 10.1172/JCI118318.

DOI:10.1172/JCI118318

PMID:8675618

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185958/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c49b/185958/1f56039dfd87/jcinvest00018-0013-a.jpg

相似文献

Gene therapy for cystic fibrosis: challenges and future directions.囊性纤维化的基因治疗：挑战与未来方向

J Clin Invest. 1995 Dec;96(6):2547-54. doi: 10.1172/JCI118318.

Challenges and strategies for cystic fibrosis lung gene therapy.囊性纤维化肺部基因治疗的挑战与策略

Mol Ther. 2001 Aug;4(2):84-91. doi: 10.1006/mthe.2001.0435.

What happens to deltaF508 in vivo?体内的ΔF508会发生什么情况？

J Clin Invest. 1999 May 15;103(10):1369-70. doi: 10.1172/JCI7119.

Developmental paradigm for early features of cystic fibrosis.囊性纤维化早期特征的发育范式。

Pediatr Pulmonol. 2005 Nov;40(5):371-7. doi: 10.1002/ppul.20169.

[Protein repair therapy in cystic fibrosis].[囊性纤维化的蛋白质修复疗法]

Rev Prat. 2003 Jan 15;53(2):163-6.

A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction.一项使用小鼠模型的演示表明，对囊性纤维化进行成功的基因治疗仅需要部分基因校正。

Gene Ther. 1996 Sep;3(9):797-801.

Update on gene therapy for cystic fibrosis.囊性纤维化基因治疗的最新进展。

Curr Opin Mol Ther. 2003 Oct;5(5):489-94.

[Genetics and cellular biology of cystic fibrosis].[囊性纤维化的遗传学与细胞生物学]

Rev Prat. 2003 Jan 15;53(2):130-4.

Gene therapy for cystic fibrosis.囊性纤维化的基因治疗。

J Gene Med. 2001 Sep-Oct;3(5):409-17. doi: 10.1002/jgm.200.

[Modifier genes and cystic fibrosis].[修饰基因与囊性纤维化]

Arch Pediatr. 2006 Jan;13(1):57-63. doi: 10.1016/j.arcped.2005.09.029. Epub 2005 Nov 7.

引用本文的文献

Gene therapy, early promises, subsequent problems, and recent breakthroughs.基因治疗：早期的前景、后续的问题及近期的突破

Adv Pharm Bull. 2013;3(2):249-55. doi: 10.5681/apb.2013.041. Epub 2013 Aug 20.

Gene delivery to the airway.基因导入气道。

Curr Protoc Hum Genet. 2013 Jul;Chapter 13:Unit 13.9. doi: 10.1002/0471142905.hg1309s78.

Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity.针对成瘾性小的分子的腺病毒疫苗被打乱，从而避开了抗腺病毒的免疫。

Hum Gene Ther. 2013 Jan;24(1):58-66. doi: 10.1089/hum.2012.163. Epub 2012 Dec 21.

Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.受体靶向纳米复合物的雾化给药用于气道上皮细胞的基因传递。

PLoS One. 2011;6(10):e26768. doi: 10.1371/journal.pone.0026768. Epub 2011 Oct 26.

L'inflammation dans la Mucoviscidose.囊性纤维化中的炎症。

Mediators Inflamm. 1996;5(2):144-69. doi: 10.1155/S0962935196000221.

Inflammation in cystic fibrosis.囊性纤维化中的炎症

Mediators Inflamm. 1996;5(2):121-43. doi: 10.1155/S096293519600021X.

Recombinant GABA(C) receptors expressed in rat hippocampal neurons after infection with an adenovirus containing the human rho1 subunit.用含人rho1亚基的腺病毒感染大鼠海马神经元后表达的重组GABA(C)受体。

J Physiol. 2001 Aug 15;535(Pt 1):145-53. doi: 10.1111/j.1469-7793.2001.00145.x.

Differential sensitivity of normal and cystic fibrosis airway epithelial cells to epinephrine.正常和囊性纤维化气道上皮细胞对肾上腺素的差异敏感性。

Br J Pharmacol. 1999 Sep;128(1):227-33. doi: 10.1038/sj.bjp.0702772.

Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene.抗凋亡的bcl-2基因可增强腺病毒介导的体内基因表达。

J Virol. 1999 Aug;73(8):6992-7000. doi: 10.1128/JVI.73.8.6992-7000.1999.

The innate immune system in cystic fibrosis lung disease.囊性纤维化肺病中的先天性免疫系统。

J Clin Invest. 1999 Feb;103(3):303-7. doi: 10.1172/JCI6277.

本文引用的文献

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment.整合素αvβ3和αvβ5促进腺病毒内化，但不促进病毒附着。

Cell. 1993 Apr 23;73(2):309-19. doi: 10.1016/0092-8674(93)90231-e.

Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.体内重组腺病毒介导的基因转移的气道上皮细胞靶标的多样性。

J Clin Invest. 1993 Jan;91(1):225-34. doi: 10.1172/JCI116175.

Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus).棉鼠（刚毛棉鼠）5型腺病毒肺炎的发病机制。

J Virol. 1993 Jan;67(1):101-11. doi: 10.1128/JVI.67.1.101-111.1993.

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.I类限制性免疫病理学机制。暴发性肝炎的转基因小鼠模型。

J Exp Med. 1993 Nov 1;178(5):1541-54. doi: 10.1084/jem.178.5.1541.

Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor.

J Clin Invest. 1993 Nov;92(5):2394-400. doi: 10.1172/JCI116845.

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes.一种胞质单纯疱疹病毒蛋白可抑制向CD8 + T淋巴细胞的抗原呈递。

Cell. 1994 May 20;77(4):525-35. doi: 10.1016/0092-8674(94)90215-1.

Lung gene therapy: in vivo adenovirus-mediated gene transfer to rhesus monkey airway epithelium.

Hum Gene Ther. 1994 Jan;5(1):3-10. doi: 10.1089/hum.1994.5.1-3.

[Ca2+]i inhibition of Ca2+ release-activated Ca2+ influx underlies agonist- and thapsigargin-induced [Ca2+]i oscillations in salivary acinar cells.胞内钙离子浓度（[Ca2+]i）对钙释放激活的钙内流的抑制作用是唾液腺腺泡细胞中激动剂和毒胡萝卜素诱导的[Ca2+]i振荡的基础。

J Biol Chem. 1994 Dec 16;269(50):31525-32.

In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung.腺病毒介导的人囊性纤维化跨膜传导调节因子cDNA转导至肺的安全性的体内评估。

Hum Gene Ther. 1994 Jun;5(6):731-44. doi: 10.1089/hum.1994.5.6-731.

Lymphocyte responses and cytokines.淋巴细胞反应与细胞因子。

Cell. 1994 Jan 28;76(2):241-51. doi: 10.1016/0092-8674(94)90332-8.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验