Karakantza M, Matutes E, MacLennan K, O'Connor N T, Srivastava P C, Catovsky D
Department of Haematology, Royal Marsden Hospital, London.
J Clin Pathol. 1996 Mar;49(3):208-12. doi: 10.1136/jcp.49.3.208.
To investigate the relation between sarcoidosis and lymphoma.
The hospital notes of five patients with sarcoidosis and a lymphoproliferative disorder were reviewed. Histological material on which the diagnoses of sarcoidosis and lymphoma were made was re-analysed.
Four of the five patients had well documented sarcoidosis preceding the development of lymphoma by 18 months to 28 years; the fifth patient had lymphoplasmacytic lymphoma with a reactive granuloma reaction. Two patients had chronic sarcoidosis and three were treated with prednisolone. The types of lymphoma were: Hodgkin's disease (n = 1), B cell lymphoma (n = 2) (mantle cell and lymphoplasmacytic/local plasmacytoma) and large granular lymphocyte leukaemia (T cell) (n = 1).
The association between sarcoidosis and lymphoma is confirmed, suggesting that sarcoidosis may be a predisposing factor for the development of a lymphoid malignancy due to disturbance of the immune system. All types of lymphoma may develop. The first case of T cell granular lymphocytic leukaemia in a patient with sarcoidosis has been documented.
研究结节病与淋巴瘤之间的关系。
回顾了5例患有结节病和淋巴增殖性疾病患者的医院病历。对做出结节病和淋巴瘤诊断的组织学材料进行了重新分析。
5例患者中有4例在淋巴瘤发生前18个月至28年有明确记录的结节病；第5例患者患有淋巴浆细胞性淋巴瘤并伴有反应性肉芽肿反应。2例患者患有慢性结节病，3例接受了泼尼松龙治疗。淋巴瘤的类型为：霍奇金病（n = 1）、B细胞淋巴瘤（n = 2）（套细胞淋巴瘤和淋巴浆细胞性/局部浆细胞瘤）和大颗粒淋巴细胞白血病（T细胞）（n = 1）。
结节病与淋巴瘤之间的关联得到证实，提示结节病可能由于免疫系统紊乱而成为淋巴恶性肿瘤发生的一个易感因素。所有类型的淋巴瘤都可能发生。已记录了首例结节病患者发生T细胞颗粒淋巴细胞白血病的病例。
