Mezzetti A, Lapenna D, Romano F, Costantini F, Pierdomenico S D, De Cesare D, Cuccurullo F, Riario-Sforza G, Zuliani G, Fellin R
Centro per lo Studio e la Terapia dell'Arteriosclerosi, Institute of Medical Physiopathology, Chieti, Italy.
J Am Geriatr Soc. 1996 Jul;44(7):823-7. doi: 10.1111/j.1532-5415.1996.tb03741.x.
It has recently been proposed that increased oxidative stress may play a role in the aging process and age-associated degenerative diseases.
A cross-sectional study was carried out to assess the relationship of circulating antioxidants, namely vitamins E and C, beta-carotene, proteic thiols (P-SH) and ceruloplasmin, and of lipid peroxides, with both aging and aging with disability, i.e., unsuccessful aging.
One hundred healthy free living and 62 disabled octo-nonagenarians and 91 healthy adults were enrolled in the study.
Free living and disabled older adults had lower antioxidant and higher lipid peroxide levels than healthy adults, as well as the disabled older adults compared with free living older persons. Using logistic regression, we observed that plasma concentrations of vitamins E and C, P-SH, and lipid peroxides were independently associated with either aging or aging with disability, apparently representing biochemical indicators of patient status. In particular, aging and unsuccessful aging were associated with higher levels of lipid peroxides independently of circulating levels of vitamins C and E, suggesting that the increased oxidative stress was not merely an effect of a lower dietary intake of antioxidants. Serum ceruloplasmin was significantly higher in free living older adults than in healthy adults, and in the disabled compared with free living octo-nonagenarians.
Our findings are consistent with the presence of systemic oxidant load in older adults, and this phenomenon is far more evident in unsuccessful aging.
最近有人提出，氧化应激增加可能在衰老过程及与年龄相关的退行性疾病中起作用。
开展了一项横断面研究，以评估循环抗氧化剂（即维生素E和C、β-胡萝卜素、蛋白质硫醇（P-SH）和铜蓝蛋白）以及脂质过氧化物与衰老和伴有残疾的衰老（即衰老失败）之间的关系。
100名健康的自由生活者、62名残疾的八九十岁老人和91名健康成年人参与了该研究。
与健康成年人相比，自由生活和残疾的老年人抗氧化剂水平较低，脂质过氧化物水平较高，而且残疾老年人与自由生活的老年人相比也是如此。通过逻辑回归分析，我们观察到维生素E和C、P-SH的血浆浓度以及脂质过氧化物与衰老或伴有残疾的衰老独立相关，显然代表了患者状态的生化指标。特别是，衰老和衰老失败与脂质过氧化物水平升高相关，且与维生素C和E的循环水平无关，这表明氧化应激增加不仅仅是抗氧化剂饮食摄入量较低的结果。自由生活的老年人血清铜蓝蛋白显著高于健康成年人，残疾老年人血清铜蓝蛋白显著高于自由生活的八九十岁老人。
我们的研究结果与老年人存在全身性氧化负荷一致，而且这种现象在衰老失败中更为明显。
