Ma J K, Hein M B
Department of Immunology, UMDS Guy's Hospital, London, UK.
Ann N Y Acad Sci. 1996 May 25;792:72-81. doi: 10.1111/j.1749-6632.1996.tb32493.x.
Plants have always been important in the pharmaceutical industry, and plant biotechnology now offers new applications. The use of heterologous expression systems for production of recombinant proteins including antibodies is no longer novel. Attention has now turned towards the end-user, and specifically to engineering the antibody to precise requirements. In expanding the choice of production systems, plants offer unique alternatives for antibody users not only in the bulk production of antibody molecules but also in the ability to assemble full-length and complex, multimeric antibodies. Although the initial investment of time and effort is substantial compared to that of other expression systems, antibody production on an agricultural scale can be envisioned, and the economy of this approach opens many new areas for potential antibody applications in addition to their traditional research and pharmaceutical uses.
植物在制药行业一直都很重要，而植物生物技术如今提供了新的应用。使用异源表达系统生产包括抗体在内的重组蛋白已不再新奇。现在关注点已转向终端用户，尤其是根据精确需求对抗体进行工程改造。在扩大生产系统的选择范围方面，植物为抗体用户提供了独特的选择，不仅体现在抗体分子的大规模生产上，还体现在组装全长且复杂的多聚体抗体的能力上。尽管与其他表达系统相比，初始投入的时间和精力相当可观，但可以设想在农业规模上生产抗体，这种方法的经济性为抗体除传统研究和制药用途之外的潜在应用开辟了许多新领域。
