The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein.
作者信息
Chen S L, Huang C H, Tsai T C, Lu K Y, Tsao Y P
机构信息
Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, Republic of China.
出版信息
Arch Virol. 1996;141(5):791-800. doi: 10.1007/BF01718155.
PMID:8678826
Abstract
In this study, we show that HPV-16 E5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevation. In addition, Ras-dependent pathway, as well as PKC-dependent pathway, leads to HPV-16 E5-induced c-jun gene expression.
摘要
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