脑特异性自身免疫性疾病中的细胞凋亡。
Apoptosis in brain-specific autoimmune disease.
作者信息
Bauer J, Wekerle H, Lassmann H
机构信息
University of Vienna, Austria.
出版信息
Curr Opin Immunol. 1995 Dec;7(6):839-43. doi: 10.1016/0952-7915(95)80057-3.
Abstract
Recent neuropathological studies of experimental autoimmune encephalomyelitis have focused attention on the high number of cells in the lesions that show typical morphological features of apoptosis. Surprisingly, it has turned out that the vast majority of apoptotic cells are T lymphocytes and that they actually represent the antigen-specific T-cell population responsible for the induction of the disease. Taken together, these data suggest that clearance of autoimmune inflammation in the nervous system is accomplished by the destruction of the antigen-specific T-cell population within the lesions. This may explain the low level of central nervous system specific T-cell memory formation, as well as previously unexplained phenomena of 'epitope spreading', in autoimmune inflammation of the nervous system.
摘要
近期对实验性自身免疫性脑脊髓炎的神经病理学研究聚焦于病变中大量呈现典型凋亡形态特征的细胞。令人惊讶的是，结果表明绝大多数凋亡细胞是T淋巴细胞，并且它们实际上代表了负责诱发该疾病的抗原特异性T细胞群体。综合来看，这些数据表明神经系统自身免疫炎症的清除是通过病变内抗原特异性T细胞群体的破坏来实现的。这可能解释了中枢神经系统特异性T细胞记忆形成水平较低的原因，以及神经系统自身免疫炎症中先前无法解释的“表位扩展”现象。
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