Watanabe K, Nishimura K, Shiode M, Sekiya M, Ikeda S, Inoue Y, Iwanaga C
Division of Internal Medicine, Minamiuwa Ehime Prefectural Hospital.
Intern Med. 1996 Feb;35(2):142-5. doi: 10.2169/internalmedicine.35.142.
In this study, we investigated the association between the drug-induced pulmonary infiltration with eosinophilia (PIE) syndrome in a patient with hypertension and the angiotensin-converting enzyme inhibitor (ACE-I) captopril. Although the patient developed diffuse lung field infiltrates accompanied by productive cough and striking peripheral eosinophilia, these symptoms disappeared after termination of the administration of captopril, pronase and cephalexine. Furthermore, the results of the peripheral lymphocyte stimulation test, skin patch test and provocation test under informed consent showed a positive reaction only for captopril. Therefore, this patient was diagnosed as captopril-induced PIE syndrome.
在本研究中，我们调查了一名高血压患者的药物性肺浸润伴嗜酸性粒细胞增多症（PIE）综合征与血管紧张素转换酶抑制剂（ACE-I）卡托普利之间的关联。尽管该患者出现了弥漫性肺野浸润，并伴有咳痰和显著的外周血嗜酸性粒细胞增多，但在停用卡托普利、链霉蛋白酶和头孢氨苄后，这些症状消失了。此外，在获得知情同意的情况下进行的外周淋巴细胞刺激试验、皮肤斑贴试验和激发试验结果显示，仅对卡托普利呈阳性反应。因此，该患者被诊断为卡托普利诱发的PIE综合征。
