Gabbay E, Small T, Corris P A
Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
Respirology. 1998 Mar;3(1):39-40. doi: 10.1046/j.1440-1843.1998.d01-2.x.
Coughing is a frequent side-effect of angiotensin converting enzyme (ACE) inhibitors. Its pathogenesis is thought to be related to the local accumulation of tachykinins although the role of extrinsic cholinergic pathways is unclear. The development of an ACE inhibitor induced cough in two patients who have undergone heart-lung transplantation and in whom cholinergic pathways remain denervated supports the hypothesis of a 'local' mechanism.
咳嗽是血管紧张素转换酶（ACE）抑制剂常见的副作用。其发病机制被认为与速激肽的局部蓄积有关，尽管外在胆碱能途径的作用尚不清楚。两名接受心肺移植且胆碱能途径仍处于失神经状态的患者发生了ACE抑制剂诱导的咳嗽，这支持了“局部”机制的假说。
