Kant R, Smith-Seemiller L, Duffy J D
Department of Psychiatry, Medical College of Pennsylvania and Hahnemann University, Allegheny General Hospital, Pittsburgh 15212, USA.
Brain Inj. 1996 Jan;10(1):55-63. doi: 10.1080/026990596124728.
An increasing number of recent reports has pointed to the underlying neuropathological substrate for obsessive-compulsive disorder (OCD). Neuropsychological testing may suggest underlying organicity even though the neuroimaging studies and the neurological examination may be normal. Earlier reports are not in agreement about the laterality of deficits. Abnormalities in frontal regions, limbic areas and basal ganglia are noted in functional neuroimaging and neuropsychological studies. In closed head injury the damage tends to be diffuse, and it is not easy to clearly localize deficits or to determine their laterality. In this paper we review the various theories and literature on OCD and organicity, and report on four individuals who developed OCD symptoms after closed head injury. We also discuss their neuroimaging and neuropsychological testing results.
最近越来越多的报告指出了强迫症（OCD）潜在的神经病理学基础。神经心理学测试可能提示潜在的器质性病变，即使神经影像学研究和神经学检查可能正常。早期报告对于缺陷的偏侧性并无一致结论。在功能神经影像学和神经心理学研究中发现额叶区域、边缘系统和基底神经节存在异常。在闭合性颅脑损伤中，损伤往往是弥漫性的，因此很难明确缺陷的定位或确定其偏侧性。在本文中，我们回顾了关于强迫症与器质性病变的各种理论和文献，并报告了4例在闭合性颅脑损伤后出现强迫症症状的患者。我们还讨论了他们的神经影像学和神经心理学测试结果。
