Bory C, Chantin C, Boulieu R
Laboratoire d'Etudes des Maladies Métaboliques, Hôpital Debrousse, Lyon, France.
J Chromatogr A. 1996 Apr 12;730(1-2):329-31. doi: 10.1016/0021-9673(95)01086-6.
A capillary electrophoretic (CE) method for the determination of hypoxanthine and xanthine in urine was developed to diagnose xanthinuria. The linearity was excellent up to 200 mumol l-1 for the two compounds and the limit of quantitation was 2 mumol l-1. A comparison o the results obtained using CE was made with those obtained by the high-performance liquid chromatographic (HPLC) technique described previously. With regard to specificity, sensitivity and reproducibility, the results are similar but CE is more rapid than HPLC.
开发了一种用于测定尿液中次黄嘌呤和黄嘌呤以诊断黄嘌呤尿症的毛细管电泳（CE）方法。两种化合物在高达200 μmol l-1时线性良好，定量限为2 μmol l-1。将CE获得的结果与先前描述的高效液相色谱（HPLC）技术获得的结果进行了比较。在特异性、灵敏度和重现性方面，结果相似，但CE比HPLC更快。
