Nyambi P N, Ville Y, Louwagie J, Bedjabaga I, Glowaczower E, Peeters M, Kerouedan D, Dazza M, Larouze B, van der Groen G, Delaporte E
Institute of Tropical Medicine, Antwerp, Belgium.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):187-92. doi: 10.1097/00042560-199606010-00013.
For 4 years. we determined the mode and risk of mother-to-child transmission of HTLV-I in a prospective cohort of 34 children born to seropositive mothers in Franceville, Gabon. We also determined the prevalence of antibodies to HTLV-I/II in siblings born to seropositive mothers. Antibodies to HTLV-I/II were detected by Western blot, and the proviral DNA was detected by the polymerase chain reaction (PCR). The risk of seroconversion to anti-HTLV-I for the 4 years of follow-up was 17.5 percent. Anti-HTLV-I/II and proviral DNA were only detected after age 18 months. We observed a seroprevalence rate of 15 percent among the siblings born to HTLV-I/II seropositive mothers. Furthermore, we report a case of mother-to-child transmission of HTLV-II infection in a population of HTLV-II-infected pregnant women that is emerging in Gabon. The lack of detection of HTLV-I/II proviral DNA in cord blood and amniotic fluid and, furthermore, the late seroconversion observed in the children indirectly indicate that mother-to-child transmission occurred postnatally, probably through breast milk.
4年来，我们在加蓬弗朗斯维尔对34名血清反应阳性母亲所生儿童的前瞻性队列中，确定了人类嗜T淋巴细胞病毒I型（HTLV-I）母婴传播的方式和风险。我们还确定了血清反应阳性母亲所生同胞中HTLV-I/II抗体的流行情况。通过蛋白质印迹法检测HTLV-I/II抗体，通过聚合酶链反应（PCR）检测前病毒DNA。随访4年中血清转化为抗HTLV-I的风险为17.5%。抗HTLV-I/II和前病毒DNA仅在18个月龄后检测到。我们观察到HTLV-I/II血清反应阳性母亲所生同胞的血清阳性率为15%。此外，我们报告了在加蓬出现的HTLV-II感染孕妇群体中发生HTLV-II母婴传播的1例病例。脐带血和羊水中未检测到HTLV-I/II前病毒DNA，而且在儿童中观察到血清转化较晚，这间接表明母婴传播发生在出生后，可能是通过母乳传播。
