Kwan C P, Tytgat G N
Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, Netherlands.
Eur J Gastroenterol Hepatol. 1995 Nov;7(11):1099-1103. doi: 10.1097/00042737-199511000-00014.
The diagnosis and management of antral gastrin-(G-) cell hyperplasia was a major topic of interest in the 1970s. Following the discovery of Helicobacter pylori in the 1980s, little attention was paid to this condition until it was shown that H. pylori infection was associated with hypergastrinaemia and that eradication of the organism returned the gastrin level to normal. Recent reports have examined the relationship between H. pylori and antral G-cell hyperplasia. H. pylori infection is present in about 50% of cases of antral G-cell hyperplasia and, importantly, eradication of the organism normalizes not only the gastrin level but also the antral G-cell count. Eradication treatment should be the therapy of choice. It is also of interest that H. pylori-negative antral G-cell hyperplasia or hyperfunction does exist. The historical aspects, the relationship between antral G-cell hyperplasia and H. pylori and recent case reports are reviewed.
胃窦胃泌素（G）细胞增生的诊断与管理是20世纪70年代备受关注的一个主要话题。20世纪80年代幽门螺杆菌被发现后，这种情况很少受到关注，直到有研究表明幽门螺杆菌感染与高胃泌素血症有关，且根除该菌可使胃泌素水平恢复正常。最近的报告探讨了幽门螺杆菌与胃窦G细胞增生之间的关系。约50%的胃窦G细胞增生病例存在幽门螺杆菌感染，重要的是，根除该菌不仅能使胃泌素水平恢复正常，还能使胃窦G细胞计数恢复正常。根除治疗应是首选治疗方法。同样有趣的是，确实存在幽门螺杆菌阴性的胃窦G细胞增生或功能亢进情况。本文回顾了其历史背景、胃窦G细胞增生与幽门螺杆菌的关系以及近期的病例报告。
