Koizumi N, Takegawa S, Mieda M, Shibata K
Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Chem Pharm Bull (Tokyo). 1996 Nov;44(11):2162-4. doi: 10.1248/cpb.44.2162.
The preparation of 6- and/or 7-substituted 3-oxo-2-oxasteroids having a spirotetrahydrofuran ring at the 17-position is described. These compounds showed high antiandrogenic potency in the castrated male rat.
描述了在17位具有螺四氢呋喃环的6-和/或7-取代的3-氧代-2-氧代甾体的制备方法。这些化合物在去势雄性大鼠中显示出高抗雄激素效力。
