Werther J L, Tatematsu M, Klein R, Kurihara M, Kumagai K, Llorens P, Guidugli Neto J, Bodian C, Pertsemlidis D, Yamachika T, Kitou T, Itzkowitz S
Department of Medicine, Mount Sinai School of Medicine, NY, USA.
Int J Cancer. 1996 Jun 21;69(3):193-9. doi: 10.1002/(SICI)1097-0215(19960621)69:3<193::AID-IJC8>3.0.CO;2-V.
Sialosyl-Tn, a mucin-associated carbohydrate antigen, is not expressed by normal mucus-producing cells of the stomach but becomes expressed in metaplastic, pre-malignant and malignant gastric tissues. Reports vary as to the frequency of STn expression and its prognostic role in gastric cancer. To determine whether these differences might be due to inter-country variations in gastric cancer biology, we immunohistochemically analyzed 340 gastric cancers from 2 countries at high-risk (high incidence) for gastric cancer (Japan and Chile), one with intermediate risk (Brazil) and one with low-risk (USA). Expression of STn was correlated with clinico-pathological features of the tumors and with cancer-related survival. Regardless of country, the frequency of STn-positive tumors was lower in non-invasive ("early") than in advanced gastric cancer. Consequently, high-risk countries where early gastric cancer is more common demonstrated a lower overall frequency of STn-positive tumors. In all 4 countries, STn expression directly correlated with depth of invasion, stage, and lymph node involvement. In addition, STn expression correlated with a poor prognosis in all 4 countries, but the effect of STn on survival was not independent of tumor stage. Our findings indicate the need to consider the inherent gastric cancer risk and prevalence of early gastric cancer in the study population when reporting frequency of STn expression in gastric cancer. Regardless of country, however, STn expression is a marker of gastric cancer progression suggesting that cancer-associated mucins play a role in the malignant behavior of this tumor.
唾液酸-Tn是一种与黏蛋白相关的碳水化合物抗原，正常胃黏液分泌细胞不表达，但在化生、癌前和恶性胃组织中表达。关于STn表达频率及其在胃癌中的预后作用，报道各不相同。为了确定这些差异是否可能归因于不同国家胃癌生物学的差异，我们对来自两个胃癌高风险（高发病率）国家（日本和智利）、一个中等风险国家（巴西）和一个低风险国家（美国）的340例胃癌进行了免疫组织化学分析。STn的表达与肿瘤的临床病理特征以及癌症相关生存率相关。无论国家如何，非侵袭性（“早期”）胃癌中STn阳性肿瘤的频率低于进展期胃癌。因此，早期胃癌更为常见的高风险国家中，STn阳性肿瘤的总体频率较低。在所有4个国家中，STn表达与浸润深度、分期和淋巴结受累直接相关。此外，在所有4个国家中，STn表达与预后不良相关，但STn对生存的影响并非独立于肿瘤分期。我们的研究结果表明，在报告胃癌中STn表达频率时，需要考虑研究人群中固有的胃癌风险和早期胃癌的患病率。然而，无论国家如何，STn表达都是胃癌进展的标志物，表明癌症相关黏蛋白在该肿瘤的恶性行为中起作用。
