Victorzon M, Nordling S, Nilsson O, Roberts P J, Haglund C
Fourth Department of Surgery, University of Helsinki, Finland.
Int J Cancer. 1996 Jan 26;65(3):295-300. doi: 10.1002/(SICI)1097-0215(19960126)65:3<295::AID-IJC3>3.0.CO;2-V.
The prognostic value of the immunohistochemical expression of Sialyl Tn antigen (STn) was evaluated in 242 patients with gastric carcinoma. Formalin-fixed, paraffin-embedded specimens of gastric adenocarcinomas were stained with the monoclonal antibody C1282, produced by immunization with ovine submaxillary mucin (OSM). Positive immunoreactivity for STn was observed in 149 (62%) patients. The expression of STn did not correlate with stage of disease (TNM), tumour location, presence of lymph-node or distant metastases, histological type, age or gender. STn immunoreactivity correlated strongly with overall survival in univariate analysis. The median survival in the STn-positive group was 21 months, in comparison to 38 months in the STn-negative group. The difference in survival between STn-negative and STn-positive tumours was significant in patients with stage-I cancer, but not in patients with stage-II -III or -IV disease. STn immunoreactivity emerged as an independent prognostic factor in Cox multivariate analysis. It is concluded that the immunohistochemical expression of STn is a good marker in the prediction of survival in patients with stage-I gastric carcinoma.
对242例胃癌患者评估了唾液酸化Tn抗原（STn）免疫组化表达的预后价值。用羊颌下粘蛋白（OSM）免疫制备的单克隆抗体C1282对福尔马林固定、石蜡包埋的胃腺癌标本进行染色。149例（62%）患者观察到STn阳性免疫反应性。STn的表达与疾病分期（TNM）、肿瘤位置、淋巴结或远处转移的存在、组织学类型、年龄或性别均无相关性。在单因素分析中，STn免疫反应性与总生存期密切相关。STn阳性组的中位生存期为21个月，而STn阴性组为38个月。在I期癌症患者中，STn阴性和STn阳性肿瘤的生存期差异显著，但在II - III期或IV期疾病患者中无差异。在Cox多因素分析中，STn免疫反应性是一个独立的预后因素。结论是，STn的免疫组化表达是预测I期胃癌患者生存期的良好标志物。
