Werther J L, Rivera-MacMurray S, Bruckner H, Tatematsu M, Itzkowitz S H
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
Br J Cancer. 1994 Mar;69(3):613-6. doi: 10.1038/bjc.1994.114.
The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer.
通过免疫组织化学方法评估原发性胃癌中唾液酸化-Tn（STn）抗原的表达情况。31例胃癌中有21例（68%）表达STn，无论肿瘤位置、分期或组织学类型如何。STn阳性肿瘤患者中81%死于疾病或发生癌症复发，而STn阴性肿瘤患者中这一比例为20%（P<0.002）。STn可能是胃癌患者有用的预后标志物。
