Wilson T, Knight T J, Beitz D C, Lewis D S, Engen R L
Department of Veterinary Physiology, Iowa State University, Ames 50011, USA.
Life Sci. 1996;59(1):PL15-21. doi: 10.1016/0024-3205(96)00260-3.
The hypothesis was tested that resveratrol, a compound in red wine, would inhibit atherosclerotic development in rabbits fed 0.5% cholesterol for 60 days. Rabbits were supplemented with or without oral resveratrol. During the study, body weights and food consumption were similar for the two groups. The lack of differences between liver weights and a series of serum parameters indicative of liver disease suggest that liver function was similar in the two groups. The diet produced hypercholesterolemia in both groups, but no differences in lipoprotein-cholesterol concentrations. The electrophoretic mobility of plasma low-density lipoprotein (LDL) and plasma LDL after induced oxidation also was not different between the groups. Staining of atherosclerotic lesions in the control and resveratrol-treated groups revealed that the resveratrol-treated rabbits had significantly more aortic surface area covered by atherosclerotic lesions (P < 0.02). Therefore, resveratrol promoted atherosclerotic development, rather than protect against it, by a mechanism that is independent of observed differences in gross animal health, liver function, plasma cholesterol concentrations, or LDL oxidative status.
红酒中的一种化合物白藜芦醇会抑制喂食0.5%胆固醇60天的兔子的动脉粥样硬化发展。兔子被给予或不给予口服白藜芦醇。在研究期间，两组兔子的体重和食物摄入量相似。肝脏重量以及一系列表明肝脏疾病的血清参数缺乏差异，这表明两组兔子的肝功能相似。该饮食在两组中均导致了高胆固醇血症，但脂蛋白胆固醇浓度没有差异。两组之间血浆低密度脂蛋白（LDL）以及诱导氧化后的血浆LDL的电泳迁移率也没有差异。对对照组和白藜芦醇处理组的动脉粥样硬化病变进行染色显示，白藜芦醇处理的兔子动脉粥样硬化病变覆盖的主动脉表面积显著更多（P < 0.02）。因此，白藜芦醇通过一种独立于所观察到的动物总体健康、肝功能、血浆胆固醇浓度或LDL氧化状态差异的机制促进了动脉粥样硬化发展，而非预防动脉粥样硬化。
