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[血栓性下肢急性缺血溶栓治疗后腘下节段的即刻再闭塞]

[Immediate reocclusion of the infrapopliteal segment after thrombolysis in acute ischemia of the lower limb of the thrombotic nature].

作者信息

Belgrano E A, Nardella L, Palladino F

机构信息

Divisione di Chirurgia Vascolare, Ospedale Civile S. Croce, Cuneo.

出版信息

Minerva Chir. 1995 Oct;50(10):879-81.

PMID:8684635
Abstract

Early reocclusion of below knee segment after fibrinolytic therapy is mainly due to thrombo-embolism, coagulopathy or to the arterial wall condition. 42 patients facing acute lower limb ischaemia because of iliofemoral thrombosis (prosthesis 19, native artery 23) underwent locoregional thrombolysis. UK was given in 33 cases while the others received rt-PA. The early reocclusion after fibrinolysis leads to a serious worsening in these patients; thrombosis in distal vessels and in microvasculature make any surgical approach unserviceable. Major amputation was required in 3 cases. We believe that fibrinolytic treatment has taken on great importance in making accurate diagnosing of thromboembolism and, once restored patency of distal vessels, allows to perform revascularization procedures.

摘要

纤维蛋白溶解疗法后膝下节段的早期再闭塞主要是由于血栓栓塞、凝血病或动脉壁状况。42例因髂股血栓形成而面临急性下肢缺血的患者(人工血管19例,天然动脉23例)接受了局部溶栓治疗。33例使用尿激酶,其余使用重组组织型纤溶酶原激活剂。纤维蛋白溶解后的早期再闭塞导致这些患者病情严重恶化;远端血管和微血管中的血栓形成使任何手术方法都无法使用。3例需要进行大截肢。我们认为,纤维蛋白溶解治疗在准确诊断血栓栓塞方面具有重要意义,并且一旦恢复远端血管通畅,就可以进行血管重建手术。

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