Zarcone R, Bellini P, Cardone G, Castagnolo A, Colacurci N
Seconda Università degli Studi di Napoli, Napoli II Cattedra dell'Istituto di Ginecologia ed Ostetricia.
Minerva Ginecol. 1996 Mar;48(3):61-3.
All phases of HPV infection are under the control of the immunitary system which is probably inhibited by the virus itself. We studied 65 patients (range 22-55 year). They presented an HPV vulvovaginal infection not healed after common therapy. The aim of our study was to verify the changes occurring in the immune system during HPV vulvo-vaginal infection. Using the immunohistochemical method we evaluated the number of T4,T8 and NK lymphocytes inside the lesion. Moreover we measured the immunitary cells of the hematic compartment. Inside the lesion we noted a reduction of the immune system in 69.23% of cases, while in the hematic compartment it was reduced only in 6.15% of cases. These data strongly suggested that the evaluation of the immunitary state, before starting therapy, is important in deciding when it would be useful to associate immunostimulating substances at the common treatment of vulvo-vaginal infection.
人乳头瘤病毒（HPV）感染的各个阶段都受免疫系统控制，而免疫系统可能受到病毒本身的抑制。我们研究了65例患者（年龄范围22至55岁）。他们患有HPV外阴阴道感染，常规治疗后未痊愈。我们研究的目的是验证HPV外阴阴道感染期间免疫系统发生的变化。我们采用免疫组织化学方法评估病变部位T4、T8和NK淋巴细胞的数量。此外，我们还测量了血液中的免疫细胞。在病变部位，我们发现69.23%的病例免疫系统有所下降，而在血液中，只有6.15%的病例免疫系统下降。这些数据强烈表明，在开始治疗前评估免疫状态对于决定在对外阴阴道感染进行常规治疗时何时联合使用免疫刺激物质是有用的，这一点很重要。
