Paudel Durga, Uehara Osamu, Giri Sarita, Yoshida Koki, Morikawa Tetsuro, Kitagawa Takao, Matsuoka Hirofumi, Miura Hiroko, Toyofuku Akira, Kuramitsu Yasuhiro, Ohta Tohru, Kobayashi Masanobu, Abiko Yoshihiro
Advanced Research Promotion Center, Health Sciences University of Hokkaido, Hokkaido, Japan.
Division of Oral Medicine and Pathology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan.
Jpn Dent Sci Rev. 2022 Nov;58:365-375. doi: 10.1016/j.jdsr.2022.11.003. Epub 2022 Nov 17.
Psychological stress in a chronic course is implicated in various diseases, such as coronary artery disease, diabetes, ulcerative colitis, and psychosomatic pain disorders. Commensal microbiota in the host tissues interact with each other and maintain overall health. Oral and gut microbiomes are considered as the most ecologically rich and taxonomically diverse microbiota communities in humans. The effects of psychological stress on the gut microbiome have been well documented, and the interaction is commonly referred as the microbiota-gut-brain axis. Like the gut microbiome, the oral microbiome contributes to maintaining both local and systemic health. Although the effects of psychological stress on the oral microbiome have been studied, comprehensive knowledge about the oral-brain axis is lacking. The oral cavity and gut can communicate with each other through the microbiota. Three-way interactions within the oral-gut-brain microbiota might exist in patients with psychological stress and disorders. The effect of psychological stress on the gut and oral microbiomes, and the potential interactions within the oral-gut-brain axis are discussed in this review.
长期的心理压力与多种疾病有关，如冠状动脉疾病、糖尿病、溃疡性结肠炎和心身疼痛障碍。宿主组织中的共生微生物群相互作用并维持整体健康。口腔和肠道微生物群被认为是人类生态最丰富、分类最多样的微生物群落。心理压力对肠道微生物群的影响已有充分记录，这种相互作用通常被称为微生物群-肠道-脑轴。与肠道微生物群一样，口腔微生物群有助于维持局部和全身健康。虽然已经研究了心理压力对口腔微生物群的影响，但缺乏关于口腔-脑轴的全面知识。口腔和肠道可以通过微生物群相互沟通。心理压力和疾病患者可能存在口腔-肠道-脑微生物群之间的三方相互作用。本文综述了心理压力对肠道和口腔微生物群的影响，以及口腔-肠道-脑轴内的潜在相互作用。
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