Moritz J D, Luftner-Nagel S, Westerhof J P, Oestmann J W, Grabbe E
Department of Radiology, University Hospital of Göttingen, Germany.
Radiology. 1996 Aug;200(2):361-3. doi: 10.1148/radiology.200.2.8685326.
To determine whether radiographically proved calcifications in core biopsy specimens are better preserved in a nonaqueous fixative than in aqueous solutions.
One hundred fifty core biopsy specimens were taken from two female breast specimens that had been preserved in ethanol. Forty-one of the specimens with radiographically proved microcalcifications were divided into four groups and deposited in four different solutions: 10% formaldehyde, 0.9% sodium chloride, electrolyte solution, and 74.1% ethanol with 10% 2-propanol. The core specimens were radiographed again after 1 and 3 days. Five ethanol-preserved specimens were also reexamined radiographically after 2 weeks.
Within 3 days, total radiographic disappearance of microcalcifications was observed in all core biopsy specimens that were immersed in solutions with high water content. In those core specimens preserved in ethanol, microcalcifications showed no change.
A nonaqueous fixative, such as ethanol, is a better preservative of microcalcifications in breast core biopsy specimens than various aqueous solutions, possibly because calcium compounds are water-soluble.
确定在非水性固定剂中，粗针活检标本中经影像学证实的钙化是否比在水溶液中保存得更好。
从保存在乙醇中的两份女性乳腺标本中获取150个粗针活检标本。41个经影像学证实有微钙化的标本被分成四组，并置于四种不同的溶液中：10%甲醛、0.9%氯化钠、电解质溶液以及含10%异丙醇的74.1%乙醇。1天和3天后再次对粗针标本进行影像学检查。5个保存在乙醇中的标本在2周后也再次进行影像学复查。
3天内，所有浸泡在高含水量溶液中的粗针活检标本中的微钙化在影像学上完全消失。而保存在乙醇中的那些粗针标本，微钙化没有变化。
非水性固定剂，如乙醇，比各种水溶液更能较好地保存乳腺粗针活检标本中的微钙化，可能是因为钙化合物是水溶性的。
