Harris S B, Perkins B A, Whalen-Brough E
Department of Family Medicine, University of Western Ontario.
Can Fam Physician. 1996 May;42:869-76.
To describe the emergence of a new clinical form of non-insulin-dependent diabetes mellitus (NIDDM) among First Nations children.
Case series developed through retrospective review of a computerized diabetes registry and of records from a hospital and clinic.
Sioux Lookout Zone Hospital, a secondary care referral hospital for 28 remote First Nations communities in northwestern Ontario, affiliated with the University of Toronto's Sioux Lookout Program.
Eighteen First Nations youths younger than 16 years identified via the Sioux Lookout Diabetes Program registry and via hospital discharge records from 1978 to 1994. Three of the 18 subjects were excluded because data essential to the study were missing from their records.
Prevalence of NIDDM in this population, clinical presentation at diagnosis, and associated risk factors (including family history, obesity, and clinical management).
Age-adjusted prevalence was 2.5/1000 in this population, the highest yet reported for NIDDM in this age group. Ratio of female to male subjects was 6:1. Typical patients were asymptomatic, obese adolescents who were not prone to ketosis and whose families had a strong history of NIDDM.
Non-insulin-dependent diabetes mellitus can occur during childhood, particularly among First Nations people.
描述北美原住民儿童中出现的一种非胰岛素依赖型糖尿病（NIDDM）的新临床类型。
通过回顾计算机化糖尿病登记系统以及医院和诊所记录形成病例系列。
苏圣玛丽地区医院，安大略省西北部28个偏远北美原住民社区的二级护理转诊医院，隶属于多伦多大学的苏圣玛丽项目。
通过苏圣玛丽糖尿病项目登记系统以及1978年至1994年的医院出院记录确定的18名16岁以下北美原住民青年。18名受试者中有3名被排除，因为其记录中缺少研究所需的关键数据。
该人群中NIDDM的患病率、诊断时的临床表现以及相关危险因素（包括家族史、肥胖和临床管理）。
该人群中年龄调整后的患病率为2.5/1000，是该年龄组中NIDDM报告的最高患病率。女性与男性受试者的比例为6:1。典型患者为无症状、肥胖的青少年，不易发生酮症，且其家族有NIDDM的强烈病史。
非胰岛素依赖型糖尿病可在儿童期发生，尤其是在北美原住民中。
