Bartlett J G
Am J Med. 1977 Jun;62(6):945-8. doi: 10.1016/0002-9343(77)90666-0.
Twelve patients with pulmonary infections presumably involving gentamicin-resistant gram-negative bacilli were evaluated for their response to amikacin therapy. All patients had hospital-acquired infections for which they had been previously treated and were considered therapeutic failures with gentamicin or tobramycin. Assessment of response to amikacin therapy showed objective evidence of clinical improvement in 11. The gentamicin-resistant organism was eradicated in nine patients although, in the majority, other gram-negative bacilli persisted in respiratory tract secretions both during and after treatment. There was one clinical failure.
对12例可能感染耐庆大霉素革兰氏阴性杆菌的肺部感染患者进行了阿米卡星治疗反应评估。所有患者均为医院获得性感染，此前曾接受治疗，但被认为是庆大霉素或妥布霉素治疗失败。对阿米卡星治疗反应的评估显示，11例有临床改善的客观证据。9例患者的耐庆大霉素病原体被根除，不过，大多数患者在治疗期间及治疗后呼吸道分泌物中仍存在其他革兰氏阴性杆菌。有1例临床治疗失败。
