Tanaka A, Hisanaga A, Hirata M, Omura M, Makita Y, Inoue N, Ishinishi N
Department of Hygiene, Faculty of Medicine, Kyushu University, Fukuoka.
Fukuoka Igaku Zasshi. 1996 May;87(5):108-15.
Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.
研究了砷化铟（InAs）和磷化铟（InP）对雄性叙利亚金仓鼠的慢性毒性。这些仓鼠每周经气管内滴注一次含总剂量为7.5mg砷或磷的InAs或InP颗粒，持续15周。作为对照，仓鼠用赋形剂磷酸盐缓冲溶液进行处理。在整个生命周期中，与对照组相比，InAs组仓鼠的累积体重增加受到显著抑制，但InP组与对照组相比则未受抑制。关于肺部的组织病理学发现，InAs或InP组中观察到的蛋白样病变、肺泡或细支气管细胞增生、肺炎、肺气肿和化生骨化的发生率显著高于对照组。从这些结果来看，InAs和InP似乎对仓鼠的肺部造成了严重损害。
