Kortmann R D, Hess C F, Meisner C, Schmidberger H, Bamberg M
Department of Radiotherapy, University of Tübingen, Germany.
Int J Radiat Oncol Biol Phys. 1996 Jul 1;35(4):779-83. doi: 10.1016/0360-3016(96)00152-6.
To assess the accuracy of field alignment in a homogeneous group of patients undergoing radiotherapy of the abdomen (adjuvant treatment of the paraaortic region in Stage I testicular seminoma). To evaluate the predictive value of the first verification on field placement errors during subsequent treatment delivery.
In 45 patients, linear and rotational discrepancies were measured between simulation and first check and between 10 consecutive verification films.
For the total group of patients, the distribution of all deviations showed mean values between 2.3 mm and -2.7 mm with standard deviations of 3.9 mm to 4.7 mm for linear discrepancies, and -0.5 degree to 0.3 degree with standard deviations of 1.2 degrees to 2.1 degrees for rotational discrepancies, respectively. For all patients, deviations for the transition from simulator to the treatment machine were similar to deviations during subsequent treatment delivery, with 95% of all absolute deviations < 10.0 mm and 4 degrees, respectively. When performing correlation analysis between deviations at first check and during treatment delivery, a correlation for lateral displacements and a borderline correlation for caudal displacements could be found. There was no correlation for cranial and rotational displacements.
Although a trend of deviations for subsequent treatment delivery may be shown at first check, our analysis indicates that the first verification cannot reliably predict inaccuracies during treatment delivery. Random fluctuations of field displacements of up to 1.0 cm prevail. They must be considered when prescribing the safety margins of the planned target volume and determining cutoff points for corrective actions in abdominal radiation therapy.
评估一组接受腹部放疗(I期睾丸精原细胞瘤腹主动脉旁区域辅助治疗)的同质患者中射野对准的准确性。评估首次验证对后续治疗过程中射野放置误差的预测价值。
对45例患者测量了模拟定位与首次检查之间以及10张连续验证片之间的线性和旋转差异。
对于所有患者,所有偏差的分布显示,线性差异的平均值在2.3毫米至-2.7毫米之间,标准差为3.9毫米至4.7毫米;旋转差异的平均值在-0.5度至0.3度之间,标准差为1.2度至2.1度。对于所有患者,从模拟定位到治疗机的偏差与后续治疗过程中的偏差相似,所有绝对偏差的95%分别<10.0毫米和4度。在首次检查时的偏差与治疗过程中的偏差之间进行相关性分析时,可发现横向位移存在相关性,尾侧位移存在临界相关性。头侧和旋转位移不存在相关性。
尽管首次检查时可能显示出后续治疗过程中偏差的趋势,但我们的分析表明,首次验证不能可靠地预测治疗过程中的不准确情况。射野位移的随机波动可达1.0厘米。在规定计划靶体积的安全裕度和确定腹部放射治疗中纠正行动的截断点时,必须考虑这些波动。