Takenaka T, Kuribayashi K, Tsukiyama M, Nakamine H, Konami S, Okada K
Department of Laboratory Medicine, Wakayama Medical School, Japan.
Rinsho Byori. 1996 Jan;44(1):81-4.
A 76-year-old woman had lymphocytosis with lymphocytes having convoluted or lobulated nuclei. These abnormal lymphocytes (leukemic cells) were positive for CD4, and some expressed IL-2R (CD25) and CD3 molecules, respectively. These morphologic and phenotypic features were compatible with adult T-cell leukemia, but serum antibodies to human T-cell lymphotropic virus type I (HTLV-I) were not detected by the particle aggregation method and an enzyme-linked immunosorbent assay. The polymerase chain reaction showed that the LTR, gag, pol, and env regions of HTLV-I proviral DNA had not been incorporated into the leukemic cells. Only the pX region was detected in these leukemic cells.
一名76岁女性出现淋巴细胞增多，淋巴细胞具有卷曲或分叶状核。这些异常淋巴细胞（白血病细胞）CD4呈阳性，部分分别表达IL-2R（CD25）和CD3分子。这些形态学和表型特征符合成人T细胞白血病，但通过颗粒凝集法和酶联免疫吸附试验未检测到针对I型人类T细胞嗜淋巴细胞病毒（HTLV-I）的血清抗体。聚合酶链反应显示，HTLV-I前病毒DNA的长末端重复序列（LTR）、gag、pol和env区域未整合到白血病细胞中。在这些白血病细胞中仅检测到pX区域。
