Yamada M, Kodama K, Fujita S, Akahoshi M, Yamada S, Hirose R, Hori M
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
Radiat Res. 1996 Aug;146(2):223-6.
About 7,000 atomic bomb (A-bomb) survivors from Hiroshima and Nagasaki who participate in the Radiation Effects Research Foundation (RERF) Adult Health Study (AHS) were examined to define the relationship between skin neoplasms and exposure to ionizing radiation. Careful clinical inspection of the skin was undertaken to detect not only skin cancer but precancerous lesions such as senile keratosis. Five cases of basal cell carcinoma, five cases of senile keratosis and one case of Bowen's disease were confirmed histologically among 5955 A-bomb survivors for whom Dosimetry System 1986 (DS86) dose estimates are available. The relationship between the combined prevalence of skin cancer and precancerous lesions and DS86 dose was examined together with other factors that might affect skin neoplasms including occupational exposure to ultraviolet (UV) rays, age, sex and city. The prevalence of basal cell carcinoma and senile keratosis increased as the DS86 dose increased. The prevalence of skin cancer and senile keratosis among persons engaged in work involving frequent exposure to UV rays was higher than among those who were not engaged in such work. Sex and city were not significantly related to those skin diseases. Odds ratios of skin neoplasm for a 1-Gy dose, occupational exposure to UV rays and age at time of examination (in 10-year increments) are 1.7, 5.9 and 1.9, respectively.
对约7000名来自广岛和长崎、参与辐射效应研究基金会（RERF）成人健康研究（AHS）的原子弹幸存者进行了检查，以确定皮肤肿瘤与电离辐射暴露之间的关系。对皮肤进行了仔细的临床检查，不仅要检测皮肤癌，还要检测癌前病变，如老年角化病。在可获得1986剂量测定系统（DS86）剂量估计值的5955名原子弹幸存者中，经组织学确诊了5例基底细胞癌、5例老年角化病和1例鲍恩病。研究了皮肤癌和癌前病变的合并患病率与DS86剂量之间的关系，以及其他可能影响皮肤肿瘤的因素，包括职业性紫外线（UV）暴露、年龄、性别和城市。基底细胞癌和老年角化病的患病率随DS86剂量的增加而增加。从事经常接触紫外线工作的人群中皮肤癌和老年角化病的患病率高于未从事此类工作的人群。性别和城市与这些皮肤病没有显著关联。每1戈瑞剂量、职业性紫外线暴露和检查时年龄（以10年为增量）的皮肤肿瘤优势比分别为1.7、5.9和1.9。
