Haková H, Misúrová E, Kropácová K
P. J. Safárik University, Faculty of Sciences, Kosice, Slovak Republic.
Vet Med (Praha). 1996 Apr;41(4):113-9.
The effect of the hepatoprotective drug silymarin (Flavobion) on the radiation injury of rats continuously irradiated with gamma rays (60Co) was studied. The rats were irradiated during 14 days by the dose rates of 0.2 and 0.6 Gy/day. In the course of irradiation the animals were treated with silymarin twice daily (70 mg/kg p. o. by tube). Silymarin effect was evaluated on the basis of quantitative changes of nucleic acids in the regenerating liver (after 70% hepatectomy), spleen, bone marrow and blood. Silymarin administration in the course of continuous gamma irradiation influenced beneficially the radiation-induced changes of DNA and RNA especially in the bone marrow.
研究了保肝药物水飞蓟素（利肝隆）对连续接受γ射线（60Co）照射的大鼠辐射损伤的影响。大鼠以0.2和0.6 Gy/天的剂量率照射14天。在照射过程中，动物每天两次接受水飞蓟素治疗（经口灌胃，70 mg/kg）。根据再生肝（70%肝切除后）、脾脏、骨髓和血液中核酸的定量变化评估水飞蓟素的效果。在连续γ照射过程中给予水飞蓟素对辐射诱导的DNA和RNA变化有有益影响，尤其是在骨髓中。
