辐射调控中的苯丙烷类化合物：双刃剑。
Phenylpropanoids in radioregulation: double edged sword.
机构信息
College of Natural Sciences Department of Biological Sciences Pusan National University Busan 609-735, Korea.
出版信息
Exp Mol Med. 2011 Jun 30;43(6):323-33. doi: 10.3858/emm.2011.43.6.034.
Abstract
Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals found in plants, have been identified as potential radiotherapeutic agents due to their anti-cancer activity and relatively safe levels of cytotoxicity. Various studies have proposed that these compounds could not only sensitize cancer cells to radiation resulting in inhibition of growth and cell death but also protect normal cells against radiation-induced damage. This review is intended to provide an overview of recent investigations on the usage of phenylpropanoids in combination with radiotherapy in cancer treatment.
摘要
放射治疗常用于治疗实体肿瘤，但存在两个主要障碍，包括放射治疗过程中癌细胞产生的获得性放射抗性和正常组织损伤。苯丙素类化合物是植物中天然存在的植物化学物质，由于其抗癌活性和相对较低的细胞毒性水平，被认为是潜在的放射治疗剂。各种研究表明，这些化合物不仅可以使癌细胞对辐射敏感，从而抑制生长和细胞死亡，还可以保护正常细胞免受辐射引起的损伤。本综述旨在概述苯丙素类化合物与放射治疗联合用于癌症治疗的最新研究进展。
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