Engan T
Department of Oncology, University Hospital of Trondheim, Norway.
Anticancer Res. 1996 May-Jun;16(3B):1461-71.
NMR spectroscopy of blood plasma has been extensively investigated in the last decade, mainly motivated by a hope that the method would aid in the diagnosis of malignant disease. Although the 1H NMR indices have failed as a tumor marker suitable for cancer screening due to low specificity, the method has great potential in cancer research. Its use outside research laboratories, however, is still very limited. Several methodological problems require special attention. 1H NMR spectroscopy lipid line widths are composite signals that reflect a continuum of general responses to different stimuli. Few studies on the fatty acid distribution in blood plasma in malignancy have been done, using the saturated and unsaturated regions of the 13C NMR spectrum. NMR spectroscopy of blood plasma might be valuable in practical clinical use. We suggest that this method could estimate effects on blood lipid profile following endocrine therapies in cancer patients.
在过去十年中，血浆的核磁共振光谱学得到了广泛研究，主要是出于该方法有助于恶性疾病诊断的期望。尽管由于特异性低，1H核磁共振指标未能作为适用于癌症筛查的肿瘤标志物，但该方法在癌症研究中具有巨大潜力。然而，其在研究实验室之外的应用仍然非常有限。几个方法学问题需要特别关注。1H核磁共振光谱学的脂质线宽是复合信号，反映了对不同刺激的一系列总体反应。利用13C核磁共振谱的饱和和不饱和区域，对恶性肿瘤患者血浆中脂肪酸分布的研究很少。血浆核磁共振光谱学在实际临床应用中可能具有价值。我们认为，这种方法可以评估癌症患者内分泌治疗后对血脂谱的影响。
