Yokozawa T, Chung H Y, He L Q, Oura H
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Biosci Biotechnol Biochem. 1996 Jun;60(6):1000-5. doi: 10.1271/bbb.60.1000.
The effects of green tea tannin on nephrectomized rats were examined. There were increases in blood urea nitrogen, serum creatinine, and urinary protein, and a decrease in creatinine clearance in the nephrectomized control rats, whereas better results for these parameters were obtained in rats given green tea tannin after nephrectomy, demonstrating a suppressed progression of the renal failure. When the renal parenchyma was partially resected, the remnant kidney showed a decrease in the activity of radical scavenger enzymes. Green tea tannin, however, was found to lighten the kidney under such oxidative stress. Mesangial proliferation and glomerular sclerotic lesions, which were conspicuous in the rats that were not given green tea tannin after nephrectomy, were also relieved.
研究了绿茶单宁对肾切除大鼠的影响。肾切除的对照大鼠血尿素氮、血清肌酐和尿蛋白增加，肌酐清除率降低，而肾切除后给予绿茶单宁的大鼠这些参数得到了更好的结果，表明肾衰竭进展受到抑制。当肾实质部分切除时，残余肾脏的自由基清除酶活性降低。然而，发现绿茶单宁可减轻这种氧化应激下的肾脏负担。肾切除后未给予绿茶单宁的大鼠中明显的系膜增生和肾小球硬化病变也得到缓解。
