金黄色葡萄球菌产生的诱导粪肠球菌质粒pAM373接合转移的葡萄球菌素-cAM373的分离与结构
Isolation and structure of staph-cAM373 produced by Staphylococcus aureus that induces conjugal transfer of Enterococcus faecalis plasmid pAM373.
作者信息
Nakayama J, Igarashi S, Nagasawa H, Clewell D B, An F Y, Suzuki A
机构信息
Department of Applied Biological Chemistry, University of Tokyo, Japan.
出版信息
Biosci Biotechnol Biochem. 1996 Jun;60(6):1038-9. doi: 10.1271/bbb.60.1038.
PMID:8695906
Abstract
Enterococus faecalis plasmid pAM373 encodes a mating response to the sex pheromone, cAM373, which is secreted from pAM373-free E. faecalis. cAM373-like activity was detected in a culture filtrate of Staphylococcus aureus. The major active substance, termed staph-cAM373, was isolated, and its structure was identified as a H-Ala-IIe-Phe-IIe-Leu-Ala-Ala-OH heptapeptide.
摘要
粪肠球菌质粒pAM373编码对性信息素cAM373的交配反应，cAM373由不含pAM373的粪肠球菌分泌。在金黄色葡萄球菌的培养滤液中检测到了cAM373样活性。分离出主要活性物质，称为葡萄球菌-cAM373，并确定其结构为H-Ala-Ile-Phe-Ile-Leu-Ala-Ala-OH七肽。
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