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粪肠球菌性信息素抑制剂iAM373的分离与结构

Isolation and structure of the sex pheromone inhibitor, iAM373, of Enterococcus faecalis.

作者信息

Nakayama J, Ono Y, Suzuki A

机构信息

Department of Applied Biological Chemistry, University of Tokyo, Japan.

出版信息

Biosci Biotechnol Biochem. 1995 Jul;59(7):1358-9. doi: 10.1271/bbb.59.1358.

DOI:10.1271/bbb.59.1358
PMID:7670199
Abstract

An Enterococcus faecalis plasmid, pAM373, has a high frequency of transfer in a liquid medium when induced by a recipient-produced sex pheromone, cAM373. The sex pheromone inhibitor against cAM373, termed iAM373, was isolated from a culture supernatant of E. faecalis harboring pAM377 (= pAM373::Tn917), and its structure was identified as a heptapeptide, H-Ser-Ile-Phe-Thr-Leu-Val-Ala-OH).

摘要

粪肠球菌质粒pAM373在由受体产生的性信息素cAM373诱导时,在液体培养基中有较高的转移频率。从携带pAM377(=pAM373::Tn917)的粪肠球菌培养上清液中分离出针对cAM373的性信息素抑制剂,称为iAM373,其结构被鉴定为一种七肽,H-丝氨酸-异亮氨酸-苯丙氨酸-苏氨酸-亮氨酸-缬氨酸-丙氨酸-OH)。

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