González Villalpando C, Stern M P, Arredondo Pérez B, Martĩnez Díaz S, González Villalpando M E, Haffner S, Rivera D, Diehl A K
Centro de Estudios en Diabetes, American British Cowdray Hospital, México, D.F.
Arch Med Res. 1996 Summer;27(2):237-41.
We present the results of a population-based survey carried out in a low income area of Mexico City. The aim of this study is to characterize the prevalence of clinically significant gallbladder disease (CSGD) using the self-reported history of cholecystectomy (CG) or cholelithiasis (CL) demonstrated by cholecystography and/or ultrasonography. The population of the studied area was 15,532 inhabitants, of whom 3505 (22.6%) were age eligible (35-64 year-old men and non-pregnant women). Home interviews were obtained in 2810 (80.2%). A physical and laboratory examination was performed in 2282 individuals (65.1%; 941 men and 1341 women). The prevalence of CSGD in men was 2.0% (95% confidence intervals 1.1-2.9%) and 9.2% in women (95% confidence intervals 7.7-10.7%). Patients with CSGD were older, men (p < 0.003) and women (p < 0.001). Women with CSGD had higher waist to hip circumference ratio (p < 0.06), higher fasting glucose (p < 0.03) as well as 2 h post challenge glycemia (p < 0.04) and insulinemia (p < 0.03). In the multiple logistic regression model only age (p < 0.001) and sex (p < 0.001) remained significantly associated. We conclude that CSGD is quite prevalent in this population. It is associated with age in both genders and in women, higher glucose and insulin levels. The prospective follow-up of this cohort is important since it could generate the information needed to implement a preventive program to diminish the impact of this condition.
我们展示了在墨西哥城一个低收入地区开展的一项基于人群的调查结果。本研究的目的是利用通过胆囊造影和/或超声检查证实的胆囊切除术（CG）或胆石症（CL）的自我报告病史，来描述具有临床意义的胆囊疾病（CSGD）的患病率。研究区域的人口为15532名居民，其中3505人（22.6%）符合年龄要求（35 - 64岁的男性和非妊娠女性）。2810人（80.2%）接受了家庭访谈。2282人（65.1%；941名男性和1341名女性）进行了体格和实验室检查。男性CSGD的患病率为2.0%（95%置信区间1.1 - 2.9%），女性为9.2%（95%置信区间7.7 - 10.7%）。患有CSGD的患者年龄较大，男性（p < 0.003）和女性（p < 0.001）均如此。患有CSGD的女性腰臀比更高（p < 0.06），空腹血糖更高（p < 0.03）以及口服葡萄糖耐量试验2小时血糖（p < 0.04）和胰岛素血症（p < 0.03）更高。在多因素逻辑回归模型中，只有年龄（p < 0.001）和性别（p < 0.001）仍具有显著相关性。我们得出结论，CSGD在该人群中相当普遍。它与两性的年龄相关，在女性中还与更高的血糖和胰岛素水平相关。对该队列进行前瞻性随访很重要，因为这可能会产生实施预防计划所需的信息，以减少这种疾病的影响。
