氯丙嗪所致低血压。与吸烟、血压及剂量的关系。

Hypotension due to chlorpromazine. Relation to cigarette smoking, blood pressure, and dosage.

作者信息

Swett C, Cole J O, Hartz S C, Shapiro S, Slone D

出版信息

Arch Gen Psychiatry. 1977 Jun;34(6):661-3. doi: 10.1001/archpsyc.1977.01770180047003.

DOI:10.1001/archpsyc.1977.01770180047003

Abstract

The frequency of hypotension attributed to orally administered chlorpromazine hydrochloride was compared among 187 nonsmokers, 223 "light" smokers, 87 "intermediate" smokers, and 18 "heavy" smokers. Hypotension attributed to the drug occurred in10%, 8%, 5% and 0%, respectively. Other factors found to be independently related to hypotension were high diastolic blood pressure on admission and high dosage of chlorpromazine. The results suggest that smoking status, dosage, and blood pressure must be evaluated in order to estimate the likelihood that a patient may become hypotensive after receiving chlorpromazine.

摘要

在187名不吸烟者、223名“轻度”吸烟者、87名“中度”吸烟者和18名“重度”吸烟者中，比较了口服盐酸氯丙嗪所致低血压的发生率。该药物所致低血压的发生率分别为10%、8%、5%和0%。其他被发现与低血压独立相关的因素是入院时舒张压高和氯丙嗪剂量大。结果表明，为了评估患者在接受氯丙嗪后可能发生低血压的可能性，必须评估吸烟状况、剂量和血压。